Proline is the dispensable amino acid in the animals. It is a cyclic compound and do not possess free amino group, but respond like alpha amino acid. It is nonessential and created in the body from glutamic acid and ornithine. From different studies, there is a close relation among the metabolism of arginine, proline, ornithine and glutamic acid. Hydroxy proline is the oxidation product of proline. There is no proof that hydroxyproline is transformed into proline. It is glycogenic and this effect is manifested after being transformed into glutamic acid.
Proline is unable to occupy a lot of of the main chain conformations effortlessly adopted by all other amino acids. Proline is unique in that it is the only amino acid where the side chain is connected to the protein backbone two times, forming a five membered nitrogen containing ring.
Proline is one of the chief components of collagen. Collagen fibres are found in the tendons, ligaments and connective tissues of the body. Proline also encourage the creation of bone, skin and cartilage and it is very important for the correct functioning of joints and tendons, also helps keep up and strengthen heart muscles and is useful in tissue repair later than injury or for any type of wound healing. Proline is also involved in energy production.
Vitamin C deficiency will cause proline to be vanished in the urine because of collagen breakdown. This is an early symbol and precursor of degenerative disease.
Proline is very vital in the process of reversing atherosclerotic deposits. The therapeutic effect is two-fold. First proline helps to stop the further build-up of atherosclerotic deposits; second proline helps to release previously deposited fat globules from the blood vessel wall into the blood stream. While many fat globules are released from the plaques in the artery walls, the deposit size decreases and leading to a reversal of cardiovascular disease.
Proline helps the body break down proteins for use in creating healthy cells in the body. It is completely necessary to the development and maintenance of healthy skin and connective tissues, particularly at the site of traumatic tissue injury.
Sources of proline
Eggs, dairy and meat are the most excellent natural sources of proline; vegetarians or those with a low-protein diet should seriously consider a mixture amino acid supplement containing among other amino acids, proline.
Benefits of proline
Proline is an amino acid required for the manufacture of collagen and cartilage. It holds muscles and joints flexible and helps decrease sagging and wrinkling that accompany UV exposure and usual aging of the skin.
Proline helps the body break down proteins for use in creating healthy cells in the body. It is completely essential to the growth and maintenance of healthy skin and connective tissues, particularly at the site of traumatic tissue injury.
Proline and lysine are both required to make hydroxyproline and hydroxylysine, 2 amino acids that form collagen. Collagen helps to heal cartilage and to cushion the combine and vertebrae. For this cause, proline supplementation may prove helpful for treatment of circumstances such as osteoarthritis, persistent soft tissue strains and chronic back pain.
The body wants proline to keep muscle tissue as well.
Proline helps to avoid the further build-up of atherosclerotic deposits; second, proline helps to release already deposited fat globules from the blood vessel wall into the blood stream.
Deficiency symptom of proline
Proline is a nonessential amino acid. The body makes proline from glutamic acid and deficiency is uncommon in healthy persons with a healthy diet.
Who need more?
People recovering from traumatic injury, mainly skin injuries such as severe burns, may desire to supplement this amino acid.
People with pain caused by deficient cartilage or collagen formation could advantage from additional proline in their diet as well.
Proline may be in supplements used to encourage cardiovascular health, typically in combination with vitamin C.
Reduces in proline levels have been illustrious in prolonged endurance runners and others following prolonged exercise. Serious athletes that subject their body to schedule, rigorous workouts may desire to take a supplement containing proline in order to keep away from loosing muscle mass the body begins to cannibalize its muscle for energy when glucose supplies run low.
Symptoms of high intake
People with kidney or liver disease should not take this or any other amino acid supplement without first consulting their physician. Getting too much of any one amino acid can throw the citric acid cycle out of stability, which makes the liver and kidneys work harder to get rid of toxins.
The suggested therapeutic dose is between 500 to 1,000 milligrams on a daily basis, in combination with vitamin C.